COVID-19 virus mutations ‘may not’ increase transmissibility

None of the mutations presently documented within the SARS-CoV-2, the virus chargeable for the Covid-19 illness, seem to increase its transmissibility in people, say researchers after analysing the virus genomes of over 46,000 individuals with Covid-19 from 99 nations. Also Read – India’s indigenous COVID-19 vaccine Covaxin phase-3 trials start in AIIMS

“The number of SARS-CoV-2 genomes being generated for scientific research is staggering,” mentioned research writer Lucy van Dorp from the University College London within the UK. Also Read – COVID-19 Live Updates: Cases in India surge to 92,66,705 whereas demise toll reaches 1,35,223

“We realised early on in the pandemic that we needed new approaches to analyse enormous amounts of data in close to real-time to flag new mutations in the virus that could affect its transmission or symptom severity,” Dorp added. Also Read – Pneumonia, rotavirus vaccines could scale back affect of COVID-19

The research, printed within the journal Nature Communications, discovered that none of those mutations is making Covid-19 unfold extra quickly.

The analysis workforce analysed a world dataset of virus genomes from 46,723 individuals with Covid-19, collected till the tip of July 2020.

The researchers have to this point recognized 12,706 mutations in SARS-CoV-2, the virus inflicting Covid-19. For 398 of the mutations, there may be sturdy proof that they’ve occurred repeatedly and independently.

Of these, the researchers honed in on 185 mutations which have occurred at the very least 3 times independently throughout the pandemic.

To check if the mutations increase transmission of the virus, the researchers modeled the virus’s evolutionary tree.

The researchers discovered no proof that any of the frequent mutations are growing the virus’s transmissibility. Instead, they discovered commonest mutations are impartial for the virus.

This contains one mutation within the virus spike protein known as D614G, which has been broadly reported as being a typical mutation that will make the virus extra transmissible.

The new proof finds that this mutation is in truth not related to considerably growing transmission.

The researchers discovered that a lot of the frequent mutations seem to have been induced by the human immune system, fairly than being the results of the virus adapting to its novel human host.

“This situation is in contrast with another analysis by the same team of what happened when SARS-CoV-2 later jumped from humans into farmed minks,” the research authors wrote.

India’s COVID-19 tally of circumstances climbed to 93.09 lakh with 43,082 new circumstances in a day, whereas 87,18,517 individuals have recuperated to this point pushing the nationwide recovery rate to 93.64 per cent on Friday.

The whole coronavirus circumstances mounted to 93,09,787 and the demise toll climbed to 1,35,715 with the novel coronavirus virus claiming 492 lives in a span of 24 hours within the nation, the information up to date at 8 am confirmed.

(With inputs from Agencies)

Published : November 27, 2020 1:38 pm | Updated:November 27, 2020 1:42 pm


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