Health

Trump’s aggressive advocacy of malaria drug for treating coronavirus divides medical community

Washington: President Donald Trump made a rare appearance in the Situation Room on Sunday as he had an epidemic task force meeting scheduled to talk about the anti-malarial drug that he had recently received as a treatment for coronovirus Is aggressively promoted.

Once again, according to a person briefed on the session, experts cautioned against the supervision of a drug that has not yet been proven to be a safe remedy, especially for heart patients. “Yes, the stuff of the heart,” Trump admitted. Then he headed out to the cameras to promote it anyway. “So what do I know?” He spoke to reporters in his daily briefing. “I am not a doctor but I have general knowledge. ”

The day after, the salesmen encouraged the chairman to try coronovirus patients to try hydroxychloroquine with the enthusiasm of a real estate developer. The reference he makes to potential threats is usually overwhelmed by full-fledged support. “What do you have to lose?” He asked five times on Sunday.

Trump, spoken by his trade advisor, a television doctor, Larry Ellison of Oracle and former New York Mayor Rudy Giuliani, has seized the drug as a miracle cure for the virus that has killed thousands and killed American lives. Has finished Along the way, he has inspired an international debate about a drug that many doctors in New York and elsewhere are trying to frustrate even without conclusive scientific studies.

Trump may eventually be right, and physicians have provided real evidence that offers hope. But this is somewhat far-fetched, and the government’s top infectious disease specialist, Dr. Anthony S. The president’s assertiveness in suppressing the case, on the advice of advisers like Fauci, has sparked a wedge inside his coronovirus task force and has raised questions about him. Desire.

If hydroxychloroquine becomes an accepted treatment, many pharmaceutical companies stand to benefit, including the president’s relationship with shareholders and senior executives. Trump himself has a small personal financial interest in Sanofi, a French drugmaker who is the brand-name version of hydroxychloroquine.

The Brooklyn Hospital Center’s medical director, Dr. Joshua Rosenberg said, “I certainly understand why the president is taking this forward.” “He is the President of the United States. He must project hope. And when you are in a situation without hope, things go awry. So I am not blaming him for taking this forward, Even though there is not much science behind it, as it is at this point, the best, most available option for use. ”

A senior doctor at Wyckoff Heights Medical Center in Brooklyn, New York, where doctors are not providing medication, however, the current demand was worrying for patients with gout diseases. At St. Barnabas Hospital in the Bronx, another doctor said his staff was delivering coronovirus patients, but the president and Gov. Andrew M. Cuomo criticized him for “cheerleading” without any evidence. “Wrong hope can also be bad,” he said.

The professional organization that published a positive French study cited by Trump’s colleagues changed his view in recent times. The International Society of Antimicrobial Chemotherapy stated, “The article does not meet the society’s expected standard.” Some hospitals in Sweden stopped providing hydroxychloroquine to treat coronovirus after reports of adverse side effects, according to Swedish news media.

But Cuomo told reporters Monday that he would ask Trump to increase the federal supply of hydroxychloroquine to New York pharmacies, allowing the state to raise the limit on purchases. Cuomo noted the lack of a formal study, saying “there is significant evidence that this is promising.”

Trump expressed interest in hydroxychloroquine a few weeks ago, telling colleagues that Alison, a billionaire and founder of Oracle, had discussed it with him. At the time, the host of television’s “The Doctor Oz Show”, Dr. Mehmat Oz was in contact with Trump’s advisers about accelerating approval to use the drug for coronovirus.

Giuliani has urged Trump to embrace the drug as a self-described simple country doctor, Drs. Vladimir is based on the advice of Zelenko, who has become a hit on conservative media after piloting a cocktail of hydroxychlorin, antibiotic azithromycin, and zinc sulfate.

In an interview on Monday, Giuliani denied any financial stake, saying he spoke with President Trump only after publicly promoting the drug. Giuliani said he turned to the issue after researching former Vice President Joe Biden in Ukraine, a project that led to the president’s impeachment.

“When I finished Biden, I immediately switched to coronovirus and I’m doing a lot of research on it,” he said. Zelenko was born in Ukraine as it happened, and when he first spoke, Giuliani mistakenly called him “Dr.” Zelensky, “Matching his name with Ukraine’s President, Volodymyr Zelensky.

Giuliani said he brought the experience of a prosecutor to his research. “One of the things that makes a good litigator is is you sort of become a quick expert on stuff, and then you forget about it,” he said. “I don’t claim to be a doctor. I repeated what he said.”

The Food and Drug Administration, which approved hydroxychloroquine as a treatment for malaria and lupus, issued an emergency order late last month allowing doctors to administer it for coronovirus patients if they Look fit Trump said that the federal government would distribute 29 million doses and requested more to Prime Minister Narendra Modi of India.

Fauci expressed his concern last week. On Fox News Friday, he said, “I think we’ve become careful that we don’t take any big leap to believe that this is a drug.” “We still need to do those types of studies that definitively prove whether any intervention, not just this, any intervention is actually safe and effective.”

On the same day, a Laxa Ingrahm, a Fox host, visited Trump at the White House with two doctors who went on his program promoting hydroxychloroquine, one of which confirmed a Washington Post report According to the official, a presentation was made on its merits.

The next day, Peter Navarro, the president’s business adviser assigned to accelerate the production of medical devices and become an advocate for drugs, defeated Fauci at a White House task force meeting, according to the discussion Gave information in

Navarro arrives at the meeting and is armed with a thick glass of research-related papers. When the issue was raised, a person told of the meeting, confirming a report from Axios, Navarro picked it up from a chair, dropped it on the table and started handing out copies.

Navarro, who earned a doctorate in economics from Harvard, defended his position on Monday despite a lack of medical credentials. “Doctors disagree about things all the time. My qualification in terms of looking at science is that I am a social scientist, ”he said on CNN. “I am a Ph.D. and I understand how to read statistical studies, whether it is medicine, law, economics or whatever.”

Trump made it clear on Sunday whose side he had taken with Nauro in a confrontation with Fauci. In his briefing after the meeting, he said that it was wrong to wait for the kind of study Fauci wanted. “We don’t have time,” the president said. “We don’t have two hours because people are dying right now.”

Some of Trump’s allies have financial interests in the issue. Sanofi’s largest shareholders include Fisher Asset Management, a mutual donor company run by Ken Fisher, a major Republican donor, including Trump. A Fisher spokesman declined to comment.

Another pharmaceutical firm, Sanofi and Mylan, has another investor, Invesco, formerly run by Wilbur Ross’s Commerce Secretary. Ross said in a statement on Monday that he “was not aware that Invesco had any investment in pharmaceutical companies,” nor did I have any involvement in the decision to detect it as a treatment. ”

As of last year, Trump reported that his three families each invest in Dodge & Cox Mutual Fund, whose largest holding was in Sanofi.

Many generic drug makers are set to manufacture hydroxychloroquine tablets, including ammonial pharmaceuticals, whose co-founder Chirag Patel is a member of Trump National Golf Course Bedminster in New Jersey and has been president at least twice since Trump became president Have been The person who saw them.

Patel, whose company is based in Bridgewater, New Jersey, did not respond to a request for comment. Amneal announced last month that it would increase production of the drug and donate millions of pills to New York and other states. Other generic drug makers are accelerating production, including Mylan and Teva Pharmaceutical Industries.

Your board member, Roberto Mignone, through Nerin Sehgal, reached out to the team of Jared Kushner, the president’s son-in-law and senior advisor, who worked for Mignon and is a friend of Kushner’s, according to information about people. Discussion.

Kushner’s team sent him to the White House task force, and Mignon sought help to ease export restrictions from India, which have since been relaxed, allowing Teva to bring more bullets into the United States. Mignone, who is also the vice president of NYU Langone Health, which is running a clinical study of hydroxychloroquine, confirmed on Monday that he had spoken to the administration about receiving more drugs in the country.

NYU Langone Health’s critical care director Drs. Daniel H. Strowman said doctors there are using hydroxychloroquine, but data regarding its effects remain “weak and unsaturated” in the study. “We don’t know if our patients are benefiting from hydroxychloroquine treatment at the present time,” he said.

Health and Hospitals Corp. of New York City, which runs its public hospitals, is advising, but doctors are not required, to use hydroxychloroquine on a trial that reduces cough and fever with mild side effects in two patients Is required, dr. Michelle Katz, who oversees this, the hospital system, said by email Monday.

Dr. Weill, Head of Infectious Diseases at Cornell Medicine. Roy M. Gulick said hydroxychloroquine was given on a case-by-case basis. “We explain the pros and cons and explain that we don’t know if it works or not,” he said.

Doctors at Northwell Health and Mount Sinai Health System are using it. At the Mount Sinai South Nassau County branch on Long Island, doctors have employed a diet of hydroxychloroquine and azithromycin “very much from day one” with mixed results, with its chief medical officer Drs. Adi Sharma said.

“We’re throwing kitchen sinks at these patients,” he said. “I can’t tell if someone got better on their own or because of the medicine.”

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