Three-year-old bone marrow donor, Bengaluru doctors give Iraqi boy a new lease of live

Written by Ralph Alex Arakal
| Bengaluru |

September 13, 2020 2:56:48 pm

Ahmed and his household after the profitable bone marrow transplant (Express picture)

A 3-year-old woman from Iraq grew to become a lifesaver for her 18-year-old brother after she donated her bone marrow for a profitable transplantation that passed off in Bengaluru.

Ahmed had undergone splenectomy in his native nation and was referred to Manipal Hospitals in Bengaluru since solely optimum therapy is obtainable in Iraq. According to doctors on the hospital, {the teenager} was additionally affected by symptomatic anemia (needing frequent blood transfusions) and jaundice.

Dr Mallikarjun Kalashetty, advisor – Haematology, Haemato-Oncology & Bone Marrow Transplantation at Manipal Hospitals, stated Ahmed required an allogeneic bone marrow transplantation.

“The best donors for such patients are the human leukocyte antigen (HLA)-matched siblings who are normal or with a minor form of haemoglobinopathy (a hereditary condition involving an abnormality in the structure of haemoglobin) or thalassaemia (a blood disorder involving lower-than-normal amounts of an oxygen-carrying protein),” Dr Kalashetty defined.

However, issues weren’t simple for the medical staff on the hospital contemplating the age of the donor — the affected person’s three-year-old youthful sister — and the apparent language barrier. Transfusion consultants on the hospital quickly realised that Ahmed would require 8-10 litres of blood whereas the donor, weighing 18 kilograms, had solely a blood quantity of about 1.3 litres.

“Considering her age, the donor had to be sedated to elicit co-operation during apheresis (extracting blood and separating components) in multiple sittings and preserve the stem cells through cryopreservation. To counter the low volume of blood going into the apheresis machine, we filled the dead spaces with compatible RBC, and to reduce the fluid overload, we determined and monitored the volume of the fluid going into the body of the child,” Dr C Shivaram, advisor – transfusion medication stated.

However, the allogeneic bone marrow transplantation was profitable and Ahmed has now recovered from the sickle-cell illness. “He did have few complications after transplantation like mucositis, febrile neutropenia, and viral reactivation, which were successfully managed,” Dr Kalashetty stated.

“Ahmed’s quality of life has improved significantly and his parents are overjoyed to see their son doing so well after suffering from the illness for several years. The satisfaction of seeing the joy on the faces of the patient and his family is unmatched,” he stated.

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