Antiviral drug used to treat cats also works against novel coronavirus, say scientists

By: PTI | Toronto |

Published: August 28, 2020 5:04:06 pm

The scientists stated they plan to check modifications of the drug to make it a good higher match contained in the virus. (AP Photo/Hassan Ammar)

A drug used to remedy a lethal viral illness in cats could also be efficient as a remedy for people against the novel coronavirus, in accordance to a research that will lead to the event of latest therapeutics to treat COVID-19.

According to the analysis, revealed within the journal Nature Communications, the drug is efficient at inhibiting viral replication in lab-grown cells contaminated with the novel coronavirus SARS-CoV-2.

“This drug is very likely to work in humans, so we’re encouraged that it will be an effective antiviral treatment for COVID-19 patients,” stated Joanne Lemieux, a professor of biochemistry on the University of Alberta.

The scientists famous that the drug interferes with the virus’ means to replicate, and will assist finish an infection.

They stated the drug is an inhibitor of a number of the physique’s protease molecules, that are key to many physique features, and are widespread targets for medicine to treat “everything from high blood pressure to cancer and HIV.”

According to the scientists, the drug was first studied following the 2002-03 SARS pandemic, following which the protease inhibitor was additional developed by veterinary researchers who confirmed it cures a illness that’s deadly in cats.

“We determined the three-dimensional shape of the protease with the drug in the active site pocket, showing the mechanism of inhibition. This will allow us to develop even more effective drugs,” Lemieux stated.

The scientists stated they plan to check modifications of the drug to make it a good higher match contained in the virus.

But, in accordance to Lemieux, the present drug exhibits sufficient antiviral motion against SARS-CoV-2 to proceed instantly to scientific trials.

“Typically for a drug to go into clinical trials, it has to be confirmed in the lab and then tested in animal models,” Lemieux stated. “Because this drug has already been used to treat cats with coronavirus, and it’s effective with little to no toxicity, it’s already passed those stages and this allows us to move forward,” she added.

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